|
KMID : 1144820180240030263
|
|
대한의생명과학회지
2018 Volume.24 No. 3 p.263 ~ p.269
|
|
|
Inhibition of 5α-reductase of de novo Generation of Short Anti-oxidant Peptides
|
|
Lee Sung-Gyu
Kang Hyun
|
|
|
Abstract
|
|
|
|
This study aims to investigate the biological activities related to hair loss of short anti-oxidant peptides (DK peptides) 5α-reductase inhibition and anti-oxidation. The series of DK peptides were generated amphipathic helical properties using leucines, lysines and tryptophan residues. Cell viability and free radical scavenging activities were performed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, respectively. The DK peptides were investigated for inhibitory activity against 5α-reductase. Antioxidant activities were determined by means of, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays. All peptides could inhibit 5α-reductase in lipopolysaccharide-stimulated macrophage. In conclusion, DK peptides was suggested as the most attractive ingredients for improving hair loss, because of the high inhibitory against 5α-reductase inhibition.
|
|
|
KEYWORD
|
|
|
5α-reductase, Anti-oxidant peptides, Hair loss
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|